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Autoimmune Hepatitis
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| | Hepatitis
The Liver
The liver is the largest organ in the body. It is found high in the right upper
abdomen, behind the ribs. It is a very complex organ and has many functions.
They include:
 | Storing energy in the form of sugar (glucose)
| Storing vitamins, iron, and other minerals
| Making proteins, including blood clotting factors, to keep the body
healthy and help it grow
| Processing worn out red blood cells
| Making bile which is needed for food digestion
| Metabolizing or breaking down many medications and alcohol
| Killing germs that enter the body through the intestine |
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The liver shoulders a heavy work load for the body, and almost never
complains. It even has a remarkable power to regenerate itself. Still, it should
not be taken for granted. The liver is subject to illnesses that can lead to
permanent damage. One example is autoimmune hepatitis, a condition in which the
body fights against its own liver. 
What is Hepatitis?
When cells in the body are injured by such things as chemicals or infection, the
area that is wounded becomes inflamed. Hepatitis is inflammation of the liver,
which in turn causes damage to individual liver cells. It is most often caused
by viral infection. However, it can also be caused by alcohol, certain drugs,
chemicals or poisons, or other diseases.
Hepatitis may be either acute or chronic. In acute hepatitis, the
inflammation develops quickly and lasts only a short period of time. The patient
usually recovers completely, but it can take up to several months. Occasionally,
a person fails to recover fully, and the hepatitis becomes chronic. In other
words, it continues at a smoldering pace. Chronic hepatitis can develop over a
number of years without the patient ever having acute hepatitis or even feeling
sick. As the liver repairs itself, fibrous tissue develops, much like a scar
forms after a cut or injury to the skin heals. Advanced scarring of the liver is
called cirrhosis. Over time, cirrhosis irreversibly damages the liver,
eventually ending in liver failure.
What is Autoimmune Hepatitis?
The immune system consists of different types of white blood cells that help to
fight infections. Some of these cells produce antibodies. Antibodies act as
warriors. They defend the body by destroying bacteria, viruses and other foreign
materials. There are different kinds of antibodies, each fighting against a
specific foreign substance. Thus, the immune system protects the body against
outside invasion by germs. But sometimes, the immune system mistakenly
recognizes the body's own organs as foreign. It can develop antibodies against
these organs. This can cause various illnesses, such as rheumatoid arthritis and
lupus. These illnesses are called autoimmune disorders because the body is
literally fighting against itself.
When the immune system attacks the liver in this way, it is called autoimmune
hepatitis. Autoimmune hepatitis is not caused by a virus or bacteria, so it is
not a contagious disease. Exactly what triggers the immune system against the
liver is unknown. The inflammation is usually chronic, and without treatment it
can cause serious injury to the liver.
 Symptoms
and Diagnosis
Autoimmune hepatitis occurs mainly in adolescent or young adult women (about 70%
of the time). However, there have also been cases of older women and men
developing the disease. Early symptoms are the same as those for most types of
hepatitis: fatigue, abdominal discomfort, and aching joints. These early
symptoms are sometimes mild and mistaken for other illnesses, such as the flu.
So, it is wise for people with these symptoms to consult a physician. When
autoimmune hepatitis progresses to severe cirrhosis, there may be jaundice
(yellow coloring to the skin and eyes), marked swelling of the abdomen from
fluid inside the abdomen, intestinal bleeding, or mental confusion.
The physician often suspects autoimmune hepatitis from the patient's medical
history. For example, patients with other autoimmune diseases -- thyroiditis,
ulcerative colitis, diabetes mellitus, vitiligo (a patchy loss of pigment in the
skin), Sjogren's syndrome (a condition causing dry eyes and mouth) -- are more
likely to have autoimmune hepatitis. A definite diagnosis of autoimmune
hepatitis is obtained with blood testing. Two antibodies that may develop in the
blood are the ANA (antinuclear antibody) and the SMA (smooth muscle antibody).
Also, a certain type of blood protein called gamma globulin is frequently
elevated. A liver biopsy is always needed to determine how much inflammation and
scarring has developed. This exam is performed under local anesthesia. A slender
needle is inserted through the right lower chest to extract a small piece of
liver tissue. The tissue is then examined under a microscope. This information
allows the physician to tailor the treatment to each individual patient.
 Treatment
The treatment of autoimmune hepatitis is aimed at curbing the autoimmune
response, and therefore the damage to liver cells. It is most effective when
begun at an early stage of the disease. In most cases, the initial treatment is
with a cortisone drug, usually prednisone (trade names: Deltasone, Orasone).
Sometimes a second drug, such as Imuran, may be added. The medication is taken
daily, usually for at least a year. The physician may attempt to taper and stop
treatment if the patient is doing well. However, a relapse often occurs, and the
medication then must be restarted and taken indefinitely. There may be side
effects with prednisone, such as swelling of the face, retention of fluid, and
weight gain. Long-term treatment with these drugs may also cause loss of bone.
This can lead to osteoporosis, or even severe damage to joints such as the
shoulder and knee. Therefore, the physician uses the lowest dosage possible to
decrease symptoms, improve liver tests, and slow liver damage.
Unfortunately, a few patients do not respond well to treatment, especially if
the disease is diagnosed late and cirrhosis is well advanced. When the patient
no longer responds to treatment with medication and liver damage is severe, a
liver transplant is considered.
Liver Transplantation
Liver transplantation is now an accepted form of treatment for chronic, severe
liver disease. Advances in surgical techniques and the use of new drugs to
suppress rejection have dramatically improved the success rate of
transplantation. The outcome for patients with autoimmune hepatitis is
excellent. Survival rates for this condition at transplant centers are well over
90 percent, with a good quality of life after recovery.
Summary
Autoimmune hepatitis is inflammation of the liver. The inflammation is a result
of the immune system developing antibodies against the liver. It is not a
contagious disease, but it is a serious chronic disease that can lead to
irreversible cirrhosis, and eventually to liver failure. However, the outlook
for patients with autoimmune hepatitis is generally very favorable. With early
diagnosis, drug treatment to prevent serious liver damage is effective in most
patients. For those few patients who do not respond to other treatment,
successful liver transplantation is now a standard form of therapy when liver
damage is severe.
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